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mavorixafor will increase the degree or result of codeine by impacting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a solid CYP2D6 inhibitor) is contraindicated with medicines that are remarkably depending on CYP2D6 for clearance.benzhydrocodone/acetaminophen and codeine both improve sedation. Prevent or Use Alternate Drug. Limit